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Dermatology

Itch and Nodule Formation in PN: The Roles of Neuronal Dysregulation and Type 2 Inflammation

Explore the pathogenesis of PN with Dr. Kim as he explains how type 2 inflammation plays a significant role in eliciting intense itching. He provides a detailed look at the mechanisms at play in PN and how they contribute to the severity of symptoms.
Brian Kim
MD
Brian Kim

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Learning objectives

  • Explain how neurogenic inflammation and a uniquely excessive neuropeptide repertoire affect sensory nerves in PN, which may cooperatively engage type 2 inflammation in a manner that results in a different quality of itch and stromal response​ 
  • Discuss how the pronounced effect of type 2 inflammation on fibroblast activation in PN may reflect differences in the nature of itch that causes patients to scratch in a particular way 
Tags
mechanism of diseasetype 2 inflammationitchneuroimmune mechanismscytokineschronic inflammation
MAT-US-2500391 v1.0 -P Exp Date: 08/01/2026

About this expert

Dermatology

Brian Kim

MD

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

See author’s profile
Brian Kim

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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