Dr Lio discusses the role of barrier disruption in AD, and the theory behind its association with environmental and food allergen sensitization.
The video explains, barrier disruption is a critical component of AD, whether due to genetic mutations like filaggrin gene mutation or overactivation of type 2 inflammatory cytokines IL-4 and IL-13. These cytokines directly damage the barrier, and scratching exacerbates this damage. Barrier disruption in AD may lead to sensitization to environmental allergens.
Clinical Professor of Dermatology at the Icahn School of Medicine at Mount Sinai, NY; Clinical Assistant Professor of Dermatology & Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois, US
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