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Dermatology
Barrier disruption in AD and the development of environmental and food allergies
Dr Casale discusses the role of barrier disruption in AD, and the theory behind its association with environmental and food allergen sensitization.
Learning objectives
- Comprehend the role of barrier disruption in atopic dermatitis, identifying causes such as genetic mutations, inflammatory cytokines, and physical damage
- Recognize the theory of how barrier disruption in atopic dermatitis may lead to sensitization to environmental allergens
Description
The video explains, barrier disruption is a critical component of AD, whether due to genetic mutations like filaggrin gene mutation or overactivation of type 2 inflammatory cytokines IL-4 and IL-13. These cytokines directly damage the barrier, and scratching exacerbates this damage. Barrier disruption in AD may lead to sensitization to environmental allergens.
Tags
MAT-US-2407525 v1.0 - R Exp Date 08/05/2026
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