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Dermatology
Barrier disruption in AD and the development of environmental and food allergies
Dr Lio discusses the role of barrier disruption in AD, and the theory behind its association with environmental and food allergen sensitization.
MD
Peter Lio
Learning objectives
- Comprehend the role of barrier disruption in atopic dermatitis, identifying causes such as genetic mutations, inflammatory cytokines, and physical damage
- Recognize the theory of how barrier disruption in atopic dermatitis may lead to sensitization to environmental allergens
Description
The video explains, barrier disruption is a critical component of AD, whether due to genetic mutations like filaggrin gene mutation or overactivation of type 2 inflammatory cytokines IL-4 and IL-13. These cytokines directly damage the barrier, and scratching exacerbates this damage. Barrier disruption in AD may lead to sensitization to environmental allergens.
Tags
MAT-US-2407525 v1.0 - R Exp Date 08/05/2026
About this expert
Dermatology
Peter Lio
MD
Clinical Professor of Dermatology at the Icahn School of Medicine at Mount Sinai, NY; Clinical Assistant Professor of Dermatology & Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois, US
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