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Dermatology

Itch in AD: Inflammation and a Dysfunctional Skin Barrier

Investigate the pathogenesis of AD with Dr. Kim, exploring how its underlying type 2 inflammation specifically drives the sensation of itch. This deep dive reveals how inflammation perpetuates discomfort and presents ongoing challenges for managing itch in AD.
Brian Kim
MD
Brian Kim

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Learning objectives

  • Understand how multiple cellular and molecular mechanisms are connected to inflammation in AD, with a major initial contribution from epidermal barrier dysfunction, as well as the mediators responsible for generating its associated itch​ 
  • Describe how subsequent scratching results in epidermal damage due to excoriation and epidermal barrier thickening, perpetuating type 2 inflammation and sensitization to itch
Tags
mechanism of diseasetype 2 inflammationbarrier dysfunctioncytokineschronic inflammation
MAT-US-2500391 v1.0 -P Exp Date: 08/01/2026

About this expert

Dermatology

Brian Kim

MD

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

See author’s profile
Brian Kim

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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