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Dermatology

Clinical Presentation and Pathophysiology of Prurigo Nodularis

The mechanisms of the neuroinflammatory, chronic itch-scratch cycle and cutaneous manifestations of pruritic nodules in prurigo nodularis.

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Learning objectives

  • Review the clinical presentation of prurigo nodularis
  • Understand the neuroinflammatory mechanisms leading to the chronic itch-scratch cycle in PN
  • Explore the link between neurogenic inflammation, skin tissue changes, and scratching in PN

Description

This short infographic outlines the clinical presentation of prurigo nodularis and the pathophysiology of the disease centering around type 2 inflammation and neuroimmune crosstalk, which propagates the neuroinflammatory itch-scratch cycle and leads to structural changes in the skin. 

Tags
disease backgroundquality of lifemechanism of disease
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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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