Skin Barrier Dysfunction and Increased Risk of Allergen Sensitization May Impact Atopic March in Atopic Dermatitis (AD)

• Understand the correlation between skin barrier dysfunction, allergen sensitization and the atopic march in AD
• Explore the potential of controlling type 2 inflammation at an early age, and potentially preventing or reducing type 2 inflammatory diseases in children with AD

An infographic on the correlation between skin barrier dysfunction, allergen sensitization, and atopic march in atopic dermatitis (AD). Skin barrier dysfunction, a common feature of AD, is a significant risk factor for allergen sensitization and subsequent progression of the atopic march. A dysfunctional skin barrier allows allergens to penetrate the skin and trigger an allergic response, ultimately leading to sensitization. This sensitization, in turn, increases the susceptibility to infections and other type 2 inflammatory diseases. To mitigate the adverse effects of skin barrier dysfunction, it is important to limit exposure to allergens and effectively manage type 2 inflammation. By addressing these factors at an early age, we can potentially prevent or delay the progression of coexisting type 2 inflammatory diseases in children with AD.