The Evolving Understanding of Prurigo Nodularis (PN) Has Implications for Patient Management

• Understand that PN is a heterogeneous, chronic inflammatory disease with unique and varied patient characteristics
• Understand that scratching in PN triggers a neuroimmune-inflammatory cycle that perpetuates itching and skin lesions
• Emerging targeted therapies hold promise for alleviating itch, reducing nodules, and improving patient-reported outcomes

An infographic on prurigo nodularis (PN): Clinical manifestations and pathophysiological processes. PN is a chronic, pruritic dermatosis characterized by itchy nodules and papules that manifest on various parts of the body. Despite its shared clinical features, PN exhibits significant heterogeneity in patient characteristics, disease burden, and clinical presentation. The pathogenesis of PN involves a vicious cycle of scratching-induced neuroimmune dysregulation and type 2 inflammation. Continuous scratching in PN results in increased neuronal signaling, further pruritus, skin fibrosis and nodule formation. Emerging targeted therapies for PN offer promising therapeutic approaches to alleviate patient burden by reducing itch and nodules, and improving sleep and quality of life.