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Dermatology

The Role of Type 2 Inflammation in Atopic Dermatitis

The impact of type 2 inflammation and barrier dysfunction in the pathogenesis of chronic disease in atopic dermatitis.

Elaine Siegfried
MD
Elaine Siegfried

Learning objectives

  • Understand that barrier function can be impacted by environmental and genetic factors
  • Explore the link between barrier function and type 2 inflammation
  • Review the impact of type 2 cytokines on various components that propagate chronic disease in AD

Description

In this short video, Prof. Elaine Siegfried summarizes the effect that barrier dysfunction has in reducing the defenses of the skin to external factors, and how type 2 cytokines can be released in response to barrier breach or underlying inflammation to propagate chronic disease in AD.

Tags
mechanism of disease
MAT-GLB-2304296 V2 08/2023

About this expert

Dermatology

Elaine Siegfried

MD

Professor of Pediatrics and Dermatology in the Department of Pediatrics, Division of Dermatology at Saint Louis University School of Medicine, US

See author’s profile
Elaine Siegfried

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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