The Impact of Skin Fibrosis in Patients with Prurigo Nodularis

• To describe the significance of skin fibrosis in prurigo nodularis
• To describe how type 2 inflammation drives fibrosis pathophysiology, contributing to scarring and nodule formation and negatively affecting patient quality of life
• To understand the interactions/contributions of type 2 cytokines, their receptors, and other molecular drivers (periostin) to the pathophysiology of fibrosis

This animated infographic explains how itch-induced scratching triggers a type 2 inflammatory response that promotes fibrosis and consequent scarring in PN, with important negative impacts on patient quality of life. The inflammatory mediators (including cytokines IL-4, IL-13 and IL-31), proteins (periostin), and key immune and skin cells involved are depicted in the context of a positive feedback loop that drives fibrosis and ultimately leads to the development of characteristic PN nodules.