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Dermatology

UCARE 2023: Potential Role of Type 2 Cytokines in CSU Pathogenesis

Dr. Saini summarises the potential role of type 2 cytokines in the pathogensis of CSU.

Sarbjit Saini
MD
Sarbjit Saini

Learning objectives

  • Highlight the potential role of type 2 cytokines in CSU pathogenesis
  • Describe how each molecule interacts with other molecules and cells to help drive pathology

Description

Dr. Saini summarises the potential role of type 2 cytokines in the pathogensis of CSU. IL-4 and IL-13 lead to cell isotype switching and cell migration. IL-31 is highlighted as a very important pruritogen. IL-33 acts by driving basophil activiation in the blood. This video was recorded at the UCARE 2023 conference during the ADVENT symposium ‘Targeting Type 2 Inflammation in CSU – Clinical and Mechanistic Implications’.

Tags
expert insightsmechanism of diseasesymposiumtype 2 inflammation
MAT-GLB-2306108 V2.0 02/2024

About this expert

Allergy/Immunology

Sarbjit Saini

MD

Professor of Medicine, Johns Hopkins University School of Medicine in Baltimore, Maryland, United States

See author’s profile
Sarbjit Saini

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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