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Dermatology

Type 2 Inflammation and Neuroimmune Axis Dysregulation in AD, PN, and CSU

Examination of the unique ways type 2 inflammation contributes to itch in AD, PN, and CSU.

Brian Kim
MD
Brian Kim

Learning objectives

  • Explore disease-specific combinations of type 2 inflammatory mediators that may underlie disease-specific itch in AD, PN, and CSU

Description

Dr. Kim explaines the different clinical course of itch in AD, PN, and CSU. He discusses the importance of epidermal barrier dysfunction in contributing to itch in atopic dermatitis, reviews the role of neurogenic inflammation and neural dysfunction in prurigo nodularis itch, and explores the central role of mast cells in CSU and associated histaminergic and nonhistaminergic itch. 

Tags
disease backgroundexpert insightsmechanism of diseasesymposium
MAT-US-2309780 v1.0 - P Expiration Date: 02/12/2026

About this expert

Dermatology

Brian Kim

MD

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

See author’s profile
Brian Kim

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MAT-US-2305040 v3.0-P Exp. Date: 11/24/2025

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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