Dermatology
The Pathophysiology of Prurigo Nodularis
An infographic exploring the pathophysiology of prurigo nodularis and the role of type 2 inflammation.
Learning objectives
- To explore the pathophysiology of PN, describing the itch-scratch cycle that drives clinical symptoms
- Describe the role of type 2 inflammation within this pathophysiology
Description
A deep dive into the pathomechanisms underlying the core clinical signs and symptoms of prurigo nodularis (PN), driven and mediated by type 2 inflammation. Type 2 cytokines (such as IL-4, IL-13 and IL-31) promote chronic itch via mediation of neuroimmune interactions and creation of a perpetual itch-scratch cycle, eventually leading to development of characteristic papulonodular skin lesions and scarring.
Tags
MAT-US-2500700 v1.0 – P Exp Date: 01/24/2027
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