An infographic exploring the pathophysiology of prurigo nodularis and the role of type 2 inflammation.
A deep dive into the pathomechanisms underlying the core clinical signs and symptoms of prurigo nodularis (PN), driven and mediated by type 2 inflammation. Type 2 cytokines (such as IL-4, IL-13 and IL-31) promote chronic itch via mediation of neuroimmune interactions and creation of a perpetual itch-scratch cycle, eventually leading to development of characteristic papulonodular skin lesions and scarring.