You have 1 action to finish to complete your account. Customize your experience by selecting your interests on the Personalization page
Dermatology
Neuroiflammation and Neurogenic Itch in Prurigo Nodularis
Dr. Chovatiya discusses the neuroinflammatory mechanisms of PN.
MD, PhD, MSCI
Raj Chovatiya
Learning objectives
- Understand how pruritogens activate sensory neurons, leading to the itch sensation and the chronic itch-scratch cycle in PN patients
- Understand how neuro-inflammatory molecules activate neurons, triggering the release of peptide signals and inflammatory cell recruitment, assess how neuronal activation contributes to the formation of pruritic papules and nodules in PN
Description
The discussion explores the mechanism of itch in PN, which originates from a pruritogen triggering sensory neurons in the skin, sending signals to the brain via the spinal column and resulting in the sensation of itch. The focus is on the neuroinflammatory pathway, where neurons interact with skin cells and inflammatory molecules, leading to the chronic itch-scratch cycle that severely affects patients’ quality of life.
Tags
MAT-GLB-2402341- 1.0 - 07/2024
About this expert
Dermatology
Raj Chovatiya
MD, PhD, MSCI
Assistant Professor of Dermatology at the Northwestern University Feinberg School of Medicine in Chicago, US
See author’s profileRelated resources
