Neuroimmune Axis Dysregulation and Type 2 Inflammation: Shared Roles in AD, PN, and CSU
Exploration of the shared type 2 inflammation and neuroimmune axis dysfunction in AD, PN, and CSU leading to itch.
Learning objectives
- Describe the role of type 2 inflammation in the development of itch in AD, PN, and CSU
- Discuss the contribution of neuroimmune axis dysregulation to the development of itch in AD, PN, and CSU
Description
Dr. Elmariah provides an overview of atopic dermatitis (AD), prurigo nodularis (PN), and chronic spontaneous uritcaria (CSU) as distinct, pruritic diseases and introduces itch pathways, including histaminergic and nonhistaminergic sensory neurons. She reviews immune responses and examines the ways type 2 inflammation can contribute to pruritus. She concludes with a discussion of the bidirectional signaling from immune cells and skin cells to sensory neurons and from sensory neurons to immune cells and skin cells, establishing the neuroimmune axis.
About this expert
Sarina Elmariah
Associate Professor and Dermatology Director at the UCSF Centre for Itch and Neurosensory Disorders at the University of California in San Francisco, California, US
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