In this plenary session at the ADVENT Gastroenterology Forum 2025, Prof. Salvatore Oliva and Dr. Milli Gupta discuss how the understanding of EoE has evolved over time, highlighting the importance of long-term management of EoE due to the chronic, progressive nature of the pathophysiology of type 2 inflammation. There are multiple approaches to more comprehensively assess symptoms, histology, and endoscopic findings, including emerging techniques such as endoFLIP