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Dermatology

What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP (Copy)

This is the full presentation of the March 2025 ADVENT cross-dermatology symposium, hosted in Orlando, Florida, presenting the latest information around type 2 inflammation and its association with atopic dermatitis (AD), prurigo nodularis (PN), chronic spontaneous urticaria (CSU) and bullous pemphigoid (BP).

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Learning objectives

  • Describe the cellular and molecular components of the type 2 immune response
  • Discuss the potential of early intervention in AD to reduce the cumulative lifetime disease burden on patients
  • Explore the mechanisms of neuroimmune dysregulation and fibrosis in PN to uncover the drivers of chronic intense itch and nodule development
  • Highlight potential roles of type 2 inflammation in CSU pathogenesis including mast cell activation, immune cell trafficking, and neuronal sensitization
  • Discuss the interplay between autoimmunity and type 2 inflammation in the pathophysiology of BP and clinical implications
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expert insightssymposiummechanism of diseaseacute exacerbations
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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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