Type 2 Inflammation
Mucus Plugging as a Potential Target in Asthma Management
Join Dr. Celeste Porsbjerg as she explores the mechanisms underlying mucus plugging development as mucociliary clearance. She explains how type 2 cytokines—particularly IL-13—impair this clearance mechanism, leading to mucus plugging, and worsened asthma outcomes.
MD, PhD
Celeste Porsbjerg
Learning objectives
- To understand how impaired mucociliary clearance driven by IL-13 leads to mucus plugging, contributing to airway obstruction and worsened asthma outcomes
- To assess type 2 cytokines drive epithelial changes that impair airway clearance and lead to structural and immune remodeling
Description
In this video clip, from the ERS 2024 symposium, Dr. Celeste Porsbjerg discusses how decreased mucociliary clearance leads to mucus plugging and worsened asthma outcomes. Highlighting the importance of targeting mucus accumulation, Dr Porsbjerg highlights the role of type 2 cytokines in driving epithelial changes that impair airway clearance, contributing to lower lung function and increased exacerbations. Also, emphasizes the importance of targeting mucus plugs to improve lung function and asthma management.
Tags
MAT-GLB-2503458 - 1.0 - 07/2025
About this expert
Pulmonology
Celeste Porsbjerg
MD, PhD
Professor of Severe Asthma, Bispebjerg Hospital Copenhagen, Denmark
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