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Dermatology

What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP

This full video presentation of the March 2025 ADVENT cross-dermatology symposium, hosted in Orlando, Florida features Dr. Eric Simpson, Dr. Shawn Kwatra, Dr. Jason Hawkes and Dr. Victoria Werth. The faculty present the latest information around type 2 inflammation and its association with atopic dermatitis (AD), prurigo nodularis (PN), chronic spontaneous urticaria (CSU) and bullous pemphigoid (BP).
Eric Simpson
Jason Hawkes
Shawn Kwatra
MD
Eric Simpson +3 more

Learning objectives

  • Describe the cellular and molecular components of the type 2 immune response
  • Discuss the potential of early intervention in AD to reduce the cumulative lifetime disease burden on patients
  • Explore the mechanisms of neuroimmune dysregulation and fibrosis in PN to uncover the drivers of chronic intense itch and nodule development
  • Highlight potential roles of type 2 inflammation in CSU pathogenesis including mast cell activation, immune cell trafficking, and neuronal sensitization
Tags
expert insightssymposiummechanism of disease
MAT-GLB-2501639 – 1.0 – 03/2025

About these experts

Dermatology
MD

Eric Simpson

Professor of Dermatology, School of Medicine, Oregon Health & Science University, Portland, US

Dermatology
MD, MS

Jason Hawkes

Dr. Hawkes is a board-certified dermatologist and Investigator at the Oregon Medical Research Center in Portland, OR and is a current Councilor in the International Psoriasis Council and serves on the NPF Medical Board and Scientific Advisory Committee

Dermatology
MD

Shawn Kwatra

Dr. Joseph W. Burnett Professor and Chair Department of Dermatology University of Maryland School of Medicine

Professor of Dermatology
Dermatology
MD

Victoria Werth

Professor of Dermatology Hospital of the University of Pennsylvania and Veteran's Administration Medical Center Philadelphia, PA

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MAT-GLB-2302957 v3.0 11/2023

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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