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EoE is a chronic, progressive type 2 inflammatory disease marked by esophageal inflammation, remodeling, fibrosis, dysfunction, and food impaction. In adults, it presents as dysphagia, food impaction, and chest pain, while in children, it may show as nonspecific symptoms like abdominal pain, vomiting, food refusal, and failure to thrive. 

Access the resources below to gain better understanding on a variety of topics related to EoE.

Type 2 asthma is a common phenotype of asthma, characterized by key cytokines IL-4, IL-13, and IL-5, as well as elevated type 2 inflammatory biomarkers as FeNO, and eosinophils, or the need for maintenance OCS. Type 2 inflammation is evident in up to 88% of patients with severe asthma, representing a substantial portion of the disease burden associated with asthma. Explore the resources below better understand the role of type 2 inflammation in asthma.

Atopic dermatitis (AD) is a chronic, relapsing, systemic disease with a high impact on the lives of patients and caregivers that requires early intervention and long-term disease control. View resources below to learn more about a variety of topics related to AD.

Bullous pemphigoid (BP) is a chronic relapsing autoimmune skin disease characterized by intense itch, inflammatory lesions, and blister formation. View the resources below to learn about a variety of topics related to BP.

Chronic spontaneous urticaria (CSU) is a chronic inflammatory disease characterized by wheals, angioedema, or both, that recur for more than 6 weeks without an identifiable trigger. View the resources below to learn about a variety of topics related to CSU.
 

Prurigo nodularis (PN) is a chronic skin disease characterized by highly pruritic nodules and associated with a high burden of disease. View the resources below to learn about a variety of topics related to PN.
 

COPD, a progressive respiratory condition, is defined by persistent airflow limitation and a spectrum of clinical presentations. There are multifaceted factors that contribute to its development and progression including complex inflammatory processes that drive the disease's pathogenesis. A profound understanding of COPD's inherent heterogeneity recognizing that it is not a singular disease, but rather a collection of phenotypes with varying underlying mechanisms and responses to treatment is crucial for advancing personalized patient care.

CRSwNP is a chronic type 2 inflammatory disease characterized by inflammation and polyp formation that obstructs the sinus and nasal passages. It presents as nasal obstruction, rhinorrhea (nasal discharge), facial pain/pressure, and reduced or complete loss of smell. The persistent symptoms can lead to breathing difficulties, sleep disturbances including snoring, chronic fatigue, and significant reduction in quality of life.

Access the resources below to gain better understanding on a variety of topics related to CRSwNP.