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Dermatology
Under the Itchy Surface: The Insidious, Cumulative Burden of Type 2 Inflammation in AD
In this video from the March 2025 ADVENT symposium in Orlando, Florida, Dr. Eric Simpson discusses the systemic nature of atopic dermatitis (AD) and how the disease burden extends beyond the skin. Through the lens of cumulative life course impairment, Dr. Simpson goes on to explore how persistent type 2 inflammation in AD may drive both atopic and nonatopic comorbidities, emphasizing the potential importance of early and effective therapeutic intervention to alter disease progression
MD
Eric Simpson
Learning objectives
- Discuss how type 2 inflammation in AD drives both local and systemic inflammatory processes, contributing to skin barrier dysfunction and increasing the risk of atopic and nonatopic comorbidities
- Examine the hidden, multidimensional burdens of uncontrolled AD, including cumulative life course impairment, and how they may become irreversible over time if left untreated
- Explore the potential for timely and effective therapeutic intervention to alter the disease course of AD and reduce the occurrence of associated comorbidities
Tags
MAT-GLB-2501640 – 1.0 – 03/2025
About this expert
Dermatology
Eric Simpson
MD
Professor of Dermatology, School of Medicine, Oregon Health & Science University, Portland, US
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