Atopic dermatitis imposes significant burden on pediatric patients, spurring research for innovative therapies in the evolving treatment landscape. In this ADVENT-sponsored symposium at the ESPD 2023 Congress in Spain, experts Michael J. Cork, MD, PhD (University of Sheffield, UK), Pablo Coto Segura, MD, PhD (Hospital Vital Alvarez-Buylla de Mieres, Spain), and Michele Ramien, MD (University of Calgary, Canada), discussed the burden of atopic dermatitis on children and their caregivers, reviewed the importance of targeting type 2 inflammation, with a particular focus on skin barrier normalization, and delved into the implications of the emerging systemic treatment landscape for practicing dermatologists.