No matches
Dermatology

The Potential Sequelae of Missed Opportunities: How Systemic Type 2 Inflammation Can Shape a Patient's Life

Dr. Nicole Chase describes a potential hypothesis for the link between the shift to an industrialized society and the rise in type 2 inflammatory diseases, highlighting the loss of immunomodulatory mechanisms driven by helminthic infections. She explains how unopposed immune responses to common environmental allergens may cause chronic type 2 inflammation, manifesting throughout the body.
Nicole Chase
MD
Nicole Chase

Related resources

CSU Burden Related to Chronicity and Patient Journey

CSU Burden Related to Chronicity and Patient Journey

expert video
ADVENT On Air | Early Intervention and Disease Modification in Atopic Dermatitis

ADVENT On Air | Early Intervention and Disease Modification in Atopic Dermatitis

Podcast
The Importance of Disease Control in Reducing CSU Patient Burden

The Importance of Disease Control in Reducing CSU Patient Burden

expert video
Broadening the Lens: Clinical and Immunological Insights That Inform CSU Management

Broadening the Lens: Clinical and Immunological Insights That Inform CSU Management

expert video
What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP

What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP

slide presentation
Targeted Approaches to Holistic Management of PN

Targeted Approaches to Holistic Management of PN

expert video
AANP 2025 | Atopic Diseases & a Case-Based Panel of Nurse Practitioners

AANP 2025 | Atopic Diseases & a Case-Based Panel of Nurse Practitioners

videoanimation
The Burden of a Lifetime: Can Disease Modification Rewrite the Narrative of Atopic Dermatitis?

The Burden of a Lifetime: Can Disease Modification Rewrite the Narrative of Atopic Dermatitis?

expert video
Beyond Clinical Control: Targeting Type 2 Inflammation for Improved Patient Outcomes

Beyond Clinical Control: Targeting Type 2 Inflammation for Improved Patient Outcomes

expert video
Cumulative Impact of Uncontrolled Atopic Dermatitis: Skin Inflammation as the Tip of the Iceberg

Cumulative Impact of Uncontrolled Atopic Dermatitis: Skin Inflammation as the Tip of the Iceberg

expert video
On the Surface: Restoring the Skin Barrier in Patients With AD

On the Surface: Restoring the Skin Barrier in Patients With AD

expert video
Charting the Future: Preventing the Atopic March

Charting the Future: Preventing the Atopic March

expert video
How Biologic Therapy May Lead to Disease Modification in Infants and Children With Atopic Dermatitis

How Biologic Therapy May Lead to Disease Modification in Infants and Children With Atopic Dermatitis

expert video
Decoding Chronic Itch and More in PN: Implications of Real-World Data for Clinical Practice

Decoding Chronic Itch and More in PN: Implications of Real-World Data for Clinical Practice

expert video
On the Surface: Restoring the Skin Barrier in Patients with AD

On the Surface: Restoring the Skin Barrier in Patients with AD

expert video
Digging Deeper: Reducing Non-Atopic Comorbidities and Multidimensional Disease Burden

Digging Deeper: Reducing Non-Atopic Comorbidities and Multidimensional Disease Burden

expert video
Early Intervention May Have the Potential to Alter the Trajectory of Atopic Dermatitis

Early Intervention May Have the Potential to Alter the Trajectory of Atopic Dermatitis

expert video
How Does Protective Type 2 Immunity Become Harmful Type 2 Inflammation?

How Does Protective Type 2 Immunity Become Harmful Type 2 Inflammation?

expert video
Decoding the Clinical Puzzle: Navigating Diagnostic Complexity Across Inflammatory Skin Diseases

Decoding the Clinical Puzzle: Navigating Diagnostic Complexity Across Inflammatory Skin Diseases

expert video
Shared and Distinct: The Role of Type 2 Inflammation in Skin Diseases

Shared and Distinct: The Role of Type 2 Inflammation in Skin Diseases

expert video
Time to Act: Reducing the Impact of Uncontrolled Disease Through Early Intervention

Time to Act: Reducing the Impact of Uncontrolled Disease Through Early Intervention

expert video
Beyond Signs and Symptoms: Broadening Treatment Goals in Dermatology

Beyond Signs and Symptoms: Broadening Treatment Goals in Dermatology

expert video
Hindered Growth in Children Aged <12 Years with Moderate-to-Severe AD and Potential Improvement with Dupilumab Treatment

Hindered Growth in Children Aged <12 Years with Moderate-to-Severe AD and Potential Improvement with Dupilumab Treatment

expert video
The Effect of Dupilumab on the Atopic March and Risk of Nonatopic Comorbidities in Pediatric Patients With AD

The Effect of Dupilumab on the Atopic March and Risk of Nonatopic Comorbidities in Pediatric Patients With AD

expert video
Can Therapy-Free Disease Control Be Achieved in Atopic Dermatitis?

Can Therapy-Free Disease Control Be Achieved in Atopic Dermatitis?

expert video
What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP

What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP

expert video
Cracking the Code: Diagnosing and Managing Skin Diseases With Type 2 Inflammation

Cracking the Code: Diagnosing and Managing Skin Diseases With Type 2 Inflammation

expert video
Understanding the Impact of Pediatric Atopic Dermatitis on Vertical Growth

Understanding the Impact of Pediatric Atopic Dermatitis on Vertical Growth

Infographic
Differential Effects of Dupilumab and JAK Inhibitors on CCL17 (TARC) in Patients With AD

Differential Effects of Dupilumab and JAK Inhibitors on CCL17 (TARC) in Patients With AD

expert video
Dupilumab Reduces Total IgE and Allergen-Specific IgE in a Real-World Study of Pediatric Patients With AD and Type 2 Comorbidities

Dupilumab Reduces Total IgE and Allergen-Specific IgE in a Real-World Study of Pediatric Patients With AD and Type 2 Comorbidities

expert video
Can Therapy-Free Disease Control Be Achieved in Atopic Dermatitis?

Can Therapy-Free Disease Control Be Achieved in Atopic Dermatitis?

expert video

Learning objectives

  • Recognize atopic dermatitis as an early manifestation of systemic type 2 inflammation
Tags
Atopic DermatitisEarly InterventionClinical ManagementPediatric
MAT-GLB-2605840 - 1.0 - 10/2026

About this expert

Allergy/Immunology
Dermatology

Nicole Chase

MD

Associate Professor of Medicine, University of Minnesota; Physician Minneapolis VA Health Care System; Partner, St. Paul Allergy & Asthma, PA

See author’s profile
Nicole Chase

ADVENT is a global medical education non-promotional program by Sanofi and Regeneron. This website is intended only for duly authenticated healthcare professionals in Algeria, Argentina, Australia, Austria, Bahrain, Belgium, Brazil, Bulgaria, Canada, Chile, China, Colombia, Costa Rica, Croatia, Czech Republic, Denmark, Dominican Republic, Ecuador, Egypt, Estonia, Finland, France, Germany, Greece, Guatemala, Hong Kong, Hungary, Iceland, India, Israel, Italy, Japan, Kuwait, Latvia, Lebanon, Lithuania, Macau, Malaysia, Norway, Oman, Panama, Peru, Poland, Portugal, Qatar, Romania, Saudi Arabia, Singapore, Slovenia, South Africa, South Korea, Spain, Sudan, Sweden, Switzerland, Taiwan, Thailand, The Netherlands, Turkey, United Arab Emirates, or the United States of America.

For healthcare professionals in Algeria: Please read the additional Terms of Use.

Sanofi | Regeneron Logo

© 2026 Sanofi and Regeneron Pharmaceuticals, Inc.

All rights reserved.
MAT-GLB-2302957 - 4.0 - 10/2025

All Rights Reserved.

Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

Country/region: ArgentinaChange country/region