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Dermatology
The Neuroimmune Axis in Itch: Complex Pathophysiology Driving an Important Clinical Symptom
How type 2 inflammation manifests as itch through various mechanisms in pruritic skin diseases such as atopic dermatitis and prurigo nodularis.
MD
Brian Kim
Learning objectives
- Review the role that type 2 inflammation plays in the generation of itch via interplay with sensory neurons in the skin
- Explore the way different mechanisms of itch manifest as different cutaneous lesions on the skin
- Understand how different ‘type 2 circuits’ result in various atopic diseases through activation of various components of the type 2 inflammatory response
Description
In this short soundbite, Dr. Brian Kim explores how type 2 inflammation in response to skin barrier breach can generate itch through the interplay of type 2 cytokines and neurons (the neuroimmune axis), resulting in the characteristic pruritus and skin lesions of atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria.
Tags
MAT-GLB-2300245 V2 03/2023
About this expert
Dermatology
Brian Kim
MD
Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US
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