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Dermatology

ADVENT On-Air Podcast: The Multifaceted Patient Burden and Drivers of Disease in Prurigo Nodularis

In this episode, Dr. Sarina Elmariah and Dr. Brian Kim explore prurigo nodularis (PN), with a focus on severe itch, fibrotic skin lesions, and their impact on patients’ quality of life. They discuss PN epidemiology, common comorbidities, and the challenges of managing multimorbid patients, while breaking down the neuroimmune mechanisms, highlighting the role of type 2 cytokines in itch and lesion development.
Sarina Elmariah
Brian Kim
MD, PhD, MPH
Sarina Elmariah +1 more

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Learning objectives

  • Describe the complex burden faced by PN patients, including common comorbidities and the impact of itch and lesions on patients’ quality of life
  • Discuss the pathophysiology of PN, focusing on mechanisms of fibrotic lesion development
Tags
type 2 inflammationBurden of Diseasecomorbiditiesitchchronic pruritusquality of life
MAT-GLB-2504334 - 1.0 - 04/2026

About these experts

Dermatology
MD, PhD, MPH

Sarina Elmariah

Associate Professor and Dermatology Director at the UCSF Centre for Itch and Neurosensory Disorders at the University of California in San Francisco, California, US

Dermatology
MD

Brian Kim

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

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MAT-GLB-2302957 - 4.0 - 10/2025

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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