35 search results for: cytokines

Itch in Chronic Inflammatory Skin Diseases: Histaminergic and Nonhistaminergic Mechanisms and Role of IL-4 as a Central Orchestrator in Promoting Neuronal Sensitization
Type 2 Inflammation
Itch in Chronic Inflammatory Skin Diseases: Histaminergic and Nonhistaminergic Mechanisms and Role of IL-4 as a Central Orchestrator in Promoting Neuronal Sensitization
expert video

In this soundbite video from the April 2025 ADVENT Forum in Lisbon, Portugal, Dr. Brian Kim explores the histaminergic and nonhistaminergic mechanisms of itch, highlighting how type 2 cytokines like IL-4 serve as central orchestrators of neuronal sensitization and immune–nervous system cross-talk.

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Type 2 Inflammation and Its Role in Atopic Dermatitis
Dermatology
Type 2 Inflammation and Its Role in Atopic Dermatitis
expert video

In this video of the October 2024 ADVENT symposium at EAPS in Vienna, Austria, Dr Christine Bangert reviews the epidemiology, clinical presentation, and differential diagnoses of AD in children, as well as the inflammatory processes driven by type 2 cytokines that lead to AD and its atopic comorbidities

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Spotlight on Type 2 Inflammation in the Upper and Lower Airways
Pulmonology
Spotlight on Type 2 Inflammation in the Upper and Lower Airways
expert video

In this video soundbite from the EAACI 2025 symposium, Dr. Zuzana Diamant explains pathophysiological mechanisms underlying asthma and CRSwNP, and how type 2 inflammatory cytokines drive airway remodelling in patients with severe asthma. Additionally, patients with co-existing asthma and CRSwNP have a higher type 2 inflammatory burden than patients with asthma alone.

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Barrier disruption in AD and the development of environmental and food allergies
Dermatology
Barrier disruption in AD and the development of environmental and food allergies
expert video

Dr. Casale discusses the critical role of barrier disruption in atopic dermatitis

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Emerging Perspectives on the Disease Burden and Management of Children With Atopic Dermatitis
Dermatology
Emerging Perspectives on the Disease Burden and Management of Children With Atopic Dermatitis
expert video

This video of the October 2024 ADVENT symposium at EAPS in Vienna, Austria features Drs Christine Bangert, Mark Boguniewicz, and Perla Lansang as they discuss the inflammatory processes driven by type 2 cytokines that lead to AD and atopic comorbidities, the multidimensional and cumulative disease burden associated with AD and its comorbidities, and the current and emerging treatment options for children with AD uncontrolled with topical therapy

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Importance of Achieving Disease Control in Adults With Moderate-to-Severe AD
Dermatology
Importance of Achieving Disease Control in Adults With Moderate-to-Severe AD
expert video

This video features Dr. Eric Simpson's presentation on the importance of achieving disease control in adults with moderate-to-severe AD. Dr. Simpson discusses how adult patients and HCPs talk about disease control and the tools available to help define it. He also explores the roles of IL-4 and IL-13 in the pathophysiology of AD, including how both cytokines promote inflammation and, in turn, contribute to the cumulative burden of the disease. The video concludes with a brief panel discussion.

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Atopic Dermatitis in Children: Can Early Therapeutic Intervention Shape Disease Course?
Dermatology
Atopic Dermatitis in Children: Can Early Therapeutic Intervention Shape Disease Course?
expert video

This video presentation of the May 2024 ADVENT symposium at ESPD’s Annual Meeting in Košice, Slovakia features Dr. Eulàlia Baselga, Dr. Amy Paller, and Prof. Lisa Weibel. The faculty investigate the inflammatory processes driven by type 2 cytokines that lead to the local and systemic clinical effects of AD, the potential benefits of treating children with AD early in the disease course, and the emerging clinical and real-world data on the use of advanced systemic treatments for children with AD.

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Early Intervention and Disease Modification in AD: Can We Change the Course of the Disease?
Dermatology
Early Intervention and Disease Modification in AD: Can We Change the Course of the Disease?
expert video

This video presentation of the September 2024 ADVENT symposium at EADV’s Annual Meeting in Amsterdam, the Netherlands features Dr. Stephan Weidinger, Dr. Eric Simpson, and Dr. Marjolein de Bruin-Weller. The faculty investigate the inflammatory processes driven by type 2 cytokines that lead to the local and systemic clinical effects of AD, the potential benefits of treating patients with AD early in the disease course, and the emerging real-world data on the use of advanced systemic therapies for patients with AD.

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Inside the Hive: Type 2 Inflammatory Pathways in Chronic Spontaneous Urticaria
Dermatology
Inside the Hive: Type 2 Inflammatory Pathways in Chronic Spontaneous Urticaria
expert video

Join Dr. Jason Hawkes in discussing the burden of CSU and how type 2 inflammation contributes to the development of chronic wheals (hives) and angioedema

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Blisters and Beyond: Autoimmunity Meets Type 2 Inflammation in Bullous Pemphigoid
Dermatology
Blisters and Beyond: Autoimmunity Meets Type 2 Inflammation in Bullous Pemphigoid
expert video

Join Dr. Victoria Werth in exploring the clinical presentation of BP and how type 2 inflammation contributes to the development of disease signs and symptoms

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Understanding the Contribution of IL-4 in the Development of Fibrosis in Prurigo Nodularis
Dermatology
Understanding the Contribution of IL-4 in the Development of Fibrosis in Prurigo Nodularis
expert video

Professor Sarina Elmariah highlights the multifaceted role of IL-4 and IL-13 in driving dermal fibrosis in prurigo nodularis, which leads to persistent scarring and dyspigmentation that significantly contribute to patients' embarrassment, anxiety, depression, and self-esteem.

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The Path to Nodules: Type 2 Inflammation at the Core of Chronic Itch and Fibrosis in Prurigo Nodularis
Type 2 Inflammation
The Path to Nodules: Type 2 Inflammation at the Core of Chronic Itch and Fibrosis in Prurigo Nodularis
expert video

Join Dr. Shawn Kwatra in discussing the diverse clinical presentations of PN and the role of type 2 inflammation in disease pathogenesis.

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