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Dermatology

Prurigo Nodularis: Type 2 Inflammation Links Neuronal Dysfunction and Fibrosis

This infographic highlights how PN is driven by type 2 inflammation, linking immune dysregulation, fibroblast activation, and neuronal dysfunction to nodule formation. It also shows how cytokine-mediated changes in neuronal architecture increase excitability and chronic itch, where resulting lesions and scarring significantly impact patients’ psychological well-being.

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Learning objectives

  • Understand how type 2 inflammation in prurigo nodularis drives immune dysregulation, neuronal dysfunction, and dermal fibrosis, leading to nodule formation
Tags
mechanism of diseasetissue remodelingtype 2 inflammationneuroimmune mechanisms
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MAT-GLB-2302957 - 4.0 - 10/2025

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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