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Type 2 Inflammation

Itch in Chronic Inflammatory Skin Diseases: Histaminergic and Nonhistaminergic Mechanisms and Role of IL-4 as a Central Orchestrator in Promoting Neuronal Sensitization

In this soundbite video from the April 2025 ADVENT Forum in Lisbon, Portugal, Dr. Brian Kim explores the histaminergic and nonhistaminergic mechanisms of itch, highlighting how type 2 cytokines like IL-4 serve as central orchestrators of neuronal sensitization and immune–nervous system cross-talk.
Brian Kim
MD
Brian Kim

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Learning objectives

  • Differentiate between histaminergic and nonhistaminergic pathways, including cytokine- and leukotriene-associated inflammation and itch
  • Explain how IL-4 functions as a regulator of type 2 inflammation and neuronal sensitization
  • Recognize the therapeutic implications of immune–nervous system communication in chronic inflammatory skin diseases
Tags
expert insightsmechanism of disease
MAT-GLB-2507496 - 1.0 - 01/2026

About this expert

Dermatology

Brian Kim

MD

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

See author’s profile
Brian Kim

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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