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Dermatology

Type 2 Cytokines Have Multiple Critical Roles in BP That Contribute to Inflammation and Itch

In this soundbite video from the April 2025 ADVENT Forum in Lisbon, Portugal, Dr. Eric Simpson outlines why early, targeted control of type 2 inflammation may modify the course of atopic dermatitis by addressing upstream drivers of barrier dysfunction, dysbiosis, and itch.
Enno Schmidt
MD, PhD
Enno Schmidt

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Learning objectives

  • Recognize the rationale for controlling type 2 inflammation in AD to achieve disease modification, including downstream effects on barrier integrity, microbial dysbiosis, neuronal activation, and pruritus
  • Understand that early inflammatory signals can precede clinical onset and support timely intervention
  • Describe how earlier, appropriate treatment may reduce cumulative life-course impairment, including long-term psychosocial burden on patients and families
Tags
disease backgroundexpert insightsmechanism of disease
MAT-GLB-2507496 - 1.0 - 01/2026

About this expert

Dermatology

Enno Schmidt

MD, PhD

Director, Lübeck Institute of Experimental Dermatology Senior Consultant, Department of Dermatology University of Lübeck, Lübeck, Germany

See author’s profile
Enno Schmidt

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MAT-GLB-2302957 - 4.0 - 10/2025

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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