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Dermatology
On demand events
What Went Wrong? How Dysregulated Type 2 Immunity Contributes to AD, PN, CSU, and BP
The March 2025 ADVENT symposium in Orlando, Florida brought together 4 dermatology experts to explore the evolving science of type 2 inflammation. Type 2 inflammation plays a central role in the pathophysiology of multiple dermatological diseases, driving chronic immune dysregulation that affects patients with atopic dermatitis (AD) prurigo nodularis (PN), chronic spontaneous urticaria (CSU) and bullous pemphigoid (BP). Understanding the mechanisms behind type 2 inflammation is key to advancing care and improving patient quality of life.
On demand materials
Learning objectives
- Describe the cellular and molecular components of the type 2 immune response
- Discuss the potential of early intervention in AD to reduce the cumulative lifetime disease burden on patients
- Explore the mechanisms of neuroimmune dysregulation and fibrosis in PN to uncover the drivers of chronic intense itch and nodule development
- Highlight potential roles of type 2 inflammation in CSU pathogenesis including mast cell activation, immune cell trafficking, and neuronal sensitization
- Discuss the interplay between autoimmunity and type 2 inflammation in the pathophysiology of BP and clinical implications
Tags
MAT-GLB-2501634 - 1.0 - 03/2025
