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Type 2 Inflammation

Underlying Type 2 Inflammation Drives a Chronic Itch-Scratch Cycle in Atopic Dermatitis

In this soundbite video from the April 2025 ADVENT Forum in Lisbon, Portugal, Dr. Brian Kim explains how underlying type 2 inflammation sustains the chronic itch-scratch cycle in atopic dermatitis, highlighting the interplay of barrier dysfunction, cytokine signaling, and neuronal activation.
Brian Kim
MD
Brian Kim

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Learning objectives

  • Describe how type 2 cytokines amplify itch-scratch and inflammatory cycles in atopic dermatitis
  • Explain the role of alarmin cytokines, Th2 polarization, and IgE production in perpetuating disease pathology
  • Recognize how cytokine-mediated pathways (IL-4, IL-13, IL-31) link immune responses to sensory neuron activation and chronic itch
Tags
expert insightsmechanism of disease
MAT-GLB-2507496 - 1.0 - 01/2026

About this expert

Dermatology

Brian Kim

MD

Professor, Vice Chair of Research, and Site Chair of Mount Sinai West, Icahn School of Medicine, NY, US

See author’s profile
Brian Kim

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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