Type 2 Inflammation and Sinonasal Barrier Dysfunction in CRSwNP

• Understand how key type 2 inflammatory mediators can disrupt sinonasal epithelial barrier function in patients with CRSwNP
• Recognize the mechanisms underlying conductive and sensorineural olfactory dysfunction as drivers of daily disease burden in CRSwNP

Chronic type 2 inflammation can compromise the sinonasal epithelial barrier in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This video examines how key type 2 inflammatory mediators disrupt the functions of ciliated cells, goblet cells, and basal cells. The video also explores how type 2 inflammation contributes to both conductive and sensorineural olfactory dysfunction — the symptom patients report as most impactful on daily life. Maintaining epithelial barrier health through management of type 2 inflammation may be key to meaningful, lasting outcomes in uncontrolled CRSwNP.