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Dermatology

Type 2 Cytokines Have Multiple Critical Roles in BP That Contribute to Inflammation and Itch

In this soundbite video from the April 2025 ADVENT Forum in Lisbon, Portugal, Prof. Enno Schmidt highlights the role of type 2 cytokines involved in the dysregulated Type 2 immune responses that contribute to inflammation and subsequent itch in bullous pemphigoid.
Enno Schmidt
MD, PhD
Enno Schmidt

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Learning objectives

  • Discuss the key roles of IL-4 and IL-13 in the complex interplay of autoimmunity and type 2 inflammation in BP, including differentiation of T cells into Th2 cells
  • Discuss stimulation of B cell proliferation, autoantibody production, and IgG to IgE class switching; immune cell activation and recruitment to skin tissue; and sensitization and stimulation of neurons and neuropeptide release
Tags
disease backgroundexpert insightsmechanism of disease
MAT-GLB-2507496 - 1.0 - 01/2026

About this expert

Dermatology

Enno Schmidt

MD, PhD

Director, Lübeck Institute of Experimental Dermatology Senior Consultant, Department of Dermatology University of Lübeck, Lübeck, Germany

See author’s profile
Enno Schmidt

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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