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Type 2 Inflammation

Type 2 Inflammation in AD Manifestations in Skin and Body

Dr. Ramien discusses the role of type 2 inflammation in the pathophysiology of atopic dermatitis, and highlights the association of atopic dermatitis with systemic diseases and comorbidities.

Michele Ramien
MD
Michele Ramien

Learning objectives

  • Understand the role of type 2 inflammation in skin barrier dysfunction and neuroimmune dysregulation
  • Examine the impact of skin dysbiosis, particularly Staphylococcus aureus overrepresentation, on inflammatory pathways and disease progression
  • Recognize the associations between atopic dermatitis and systemic comorbidities

Description

Exploring patho-mechanisms of atopic dermatitis, with a focus on type 2 inflammation, disruptions in the skin barrier, dysbiosis in the microbiome, and alterations in the neuroimmune system, highlighting the association of atopic dermatitis with systemic diseases and comorbidities, such as cardiovascular disease, mental health issues, ocular abnormalities, and decreased bone health. 

Tags
expert insightsmechanism of disease
MAT-GLB-2402300 - 1.0 - 07/2024

About this expert

Dermatology

Michele Ramien

MD

Clinician-Investigator at the Alberta Children’s Hospital in Calgary, Alberta, Canada

See author’s profile
Michele Ramien

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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