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Dermatology

Understanding the Contribution of IL-4 in the Development of Fibrosis in Prurigo Nodularis

Professor Sarina Elmariah highlights the multifaceted role of IL-4 and IL-13 in driving dermal fibrosis in prurigo nodularis, which leads to persistent scarring and dyspigmentation that significantly contribute to patients' embarrassment, anxiety, depression, and self-esteem.
Sarina Elmariah
MD, PhD, MPH
Sarina Elmariah

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Learning objectives

  • Understand the unique mechanisms by which IL-4/IL-13 contribute to dermal fibrosis in PN
Tags
IL-4IL-13chronic inflammationchronic prurituscytokines
MAT-GLB-2600443 - 1.0 - 02/2026

About this expert

Dermatology

Sarina Elmariah

MD, PhD, MPH

Associate Professor and Dermatology Director at the UCSF Centre for Itch and Neurosensory Disorders at the University of California in San Francisco, California, US

See author’s profile
Sarina Elmariah

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Sanofi and Regeneron are global leaders in pharmaceutical development, each with a long history of supporting frontline physicians to improve human health and reduce the burden of disease. Driven by the same commitment to patients and their families, Sanofi and Regeneron have partnered to take on type 2 inflammation and the range of chronic conditions in which excessive inflammation plays a role.

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